Having watched the original as my first ever anime many years ago, I was skeptical to move onto brotherhood. After many years I decided to finally take the plunge. The first 4 episodes are a bit confusing (perhaps because I had watched the original, you may have less of a problem if you haven't). Everything after that left me speechless. 64 episodes spent going "oh just one more", early nights turning into 4am marathons. I have never felt a greater range of emotion when watching anime.
This is the undisputed king of anime, there is nothing better, there may well never be anything better.